Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI AF_1	GS	9.45e-05	2.53e-05	1.27e-05	1.67e-07
GS	spliceAI AF_1	5.33e-01	1.55e-01	5.87e-02	5.46e-02



Evaluating how well spliceAI AF_1 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_1	GS	0.82	3.17	5.63	3.27	5.48
GS	spliceAI AF_1	0.60	1.92	1.78	1.99	2.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_1	GS	0.00	6.03	9.18	3.73	8.56
GS	spliceAI AF_1	0.00	4.11	4.04	4.19	4.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI AF_1	56	54	AC010326.2;AL132671.2
GS	25	25