Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI AF_0001	GS	5.53e-01	3.46e-01	1.55e-01	1.92e-02
GS	spliceAI AF_0001	5.74e-01	8.77e-02	8.37e-02	2.92e-03



Evaluating how well spliceAI AF_0001 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_0001	GS	0.66	0.94	1.22	0.77	2.63
GS	spliceAI AF_0001	0.64	1.51	1.50	1.23	2.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_0001	GS	0.00	0.49	0.69	0.48	0.42
GS	spliceAI AF_0001	0.00	0.69	0.97	0.74	1.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI AF_0001	31	29	AC010326.2;AL132671.2
GS	25	25