Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_femal_AD10K_z3_150 Exclusive	adgs	8.82e-03	5.14e-04	8.59e-05	4.54e-07
adgs Exclusive	mu_femal_AD10K_z3_150	4.10e-02	4.70e-01	3.82e-01	7.16e-01
mu_femal_AD10K_z3_150 Exclusive	adgs Exclusive	1.08e-02	2.24e-03	1.66e-04	4.22e-06
adgs Exclusive	mu_femal_AD10K_z3_150 Exclusive	2.56e-02	3.74e-01	7.07e-01	7.39e-01
mu_femal_AD10K_z3_150 Exclusive	Overlap	5.47e-02	1.36e-01	1.73e-02	1.13e-03
adgs Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.22e-03	1.64e-04	8.00e-19	7.10e-07



Evaluating how well mu_femal_AD10K_z3_150 genes are linked to adgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_femal_AD10K_z3_150 Exclusive	adgs	0.77	1.91	3.67	1.85	4.51
adgs Exclusive	mu_femal_AD10K_z3_150	0.52	-1.17	-1.10	-0.97	0.93
mu_femal_AD10K_z3_150 Exclusive	adgs Exclusive	0.74	1.87	3.57	1.93	4.36
adgs Exclusive	mu_femal_AD10K_z3_150 Exclusive	0.51	-1.62	-1.40	-1.15	0.30
mu_femal_AD10K_z3_150 Exclusive	Overlap	0.97	1.88	2.34	2.07	2.94
adgs Exclusive	Overlap	1.00	2.73	2.51	2.50	3.00
Overlap	Exclusives	0.62	2.71	4.89	3.09	5.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_femal_AD10K_z3_150 Exclusive	adgs	0.00	2.49	6.17	1.52	7.69
adgs Exclusive	mu_femal_AD10K_z3_150	0.01	3.04	4.33	4.11	4.51
mu_femal_AD10K_z3_150 Exclusive	adgs Exclusive	0.00	0.24	4.10	1.38	3.45
adgs Exclusive	mu_femal_AD10K_z3_150 Exclusive	0.01	1.04	1.39	1.98	1.62
mu_femal_AD10K_z3_150 Exclusive	Overlap	0.01	6.00	8.84	9.40	10.90
adgs Exclusive	Overlap	0.06	165.38	234.57	207.41	35.89
Overlap	Exclusives	0.04	28.13	40.21	25.76	29.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_femal_AD10K_z3_150 Exclusive	147	144	RAB6D;C22orf46;RFPL2
adgs Exclusive	22	22	
Overlap	3	3