Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_male_AD10K_z3_192 Exclusive	adgs	8.93e-04	8.27e-05	7.29e-06	1.13e-07
adgs Exclusive	mu_male_AD10K_z3_192	5.06e-01	7.38e-02	1.76e-03	1.10e-02
mu_male_AD10K_z3_192 Exclusive	adgs Exclusive	8.24e-03	7.22e-04	1.29e-04	1.06e-05
adgs Exclusive	mu_male_AD10K_z3_192 Exclusive	7.36e-01	7.48e-02	2.68e-03	1.88e-02
mu_male_AD10K_z3_192 Exclusive	Overlap	6.83e-02	7.71e-02	1.21e-02	2.44e-04
adgs Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.23e-03	1.28e-03	4.13e-24	3.10e-05



Evaluating how well mu_male_AD10K_z3_192 genes are linked to adgs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_male_AD10K_z3_192 Exclusive	adgs	0.81	2.84	4.56	2.77	5.41
adgs Exclusive	mu_male_AD10K_z3_192	0.55	1.71	2.11	2.01	2.37
mu_male_AD10K_z3_192 Exclusive	adgs Exclusive	0.79	1.97	3.92	2.50	5.04
adgs Exclusive	mu_male_AD10K_z3_192 Exclusive	0.55	1.75	1.77	1.88	2.08
mu_male_AD10K_z3_192 Exclusive	Overlap	0.98	2.21	2.39	2.48	3.62
adgs Exclusive	Overlap	1.00	2.94	2.52	2.74	2.87
Overlap	Exclusives	0.59	3.27	4.42	2.95	4.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_male_AD10K_z3_192 Exclusive	adgs	0.01	5.37	14.84	8.51	18.14
adgs Exclusive	mu_male_AD10K_z3_192	0.02	4.92	4.93	5.06	6.73
mu_male_AD10K_z3_192 Exclusive	adgs Exclusive	0.01	4.00	5.64	5.45	4.58
adgs Exclusive	mu_male_AD10K_z3_192 Exclusive	0.01	2.35	1.79	3.19	3.95
mu_male_AD10K_z3_192 Exclusive	Overlap	0.01	2.88	28.05	19.11	22.34
adgs Exclusive	Overlap	0.09	270.15	166.22	410.40	108.71
Overlap	Exclusives	0.04	31.96	21.33	27.55	35.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_male_AD10K_z3_192 Exclusive	189	187	PRAMEF11;RFPL2
adgs Exclusive	22	22	
Overlap	3	3