Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA spliceAI AF_1 Exclusive	somatic	2.14e-02	1.01e-01	7.62e-01	1.15e-08
somatic Exclusive	BRCA spliceAI AF_1	9.36e-01	3.25e-01	1.04e-03	4.82e-01
BRCA spliceAI AF_1 Exclusive	somatic Exclusive	4.98e-02	1.85e-01	6.47e-01	1.50e-08
somatic Exclusive	BRCA spliceAI AF_1 Exclusive	9.68e-01	3.33e-01	7.38e-04	5.65e-01
BRCA spliceAI AF_1 Exclusive	Overlap	1.58e-01	1.98e-02	3.76e-01	1.98e-01
somatic Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.38e-04	1.33e-07	8.87e-17	1.04e-12



Evaluating how well BRCA spliceAI AF_1 genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA spliceAI AF_1 Exclusive	somatic	0.79	1.87	2.66	0.57	6.77
somatic Exclusive	BRCA spliceAI AF_1	0.53	1.61	1.28	0.58	0.88
BRCA spliceAI AF_1 Exclusive	somatic Exclusive	0.79	1.64	2.63	0.55	6.34
somatic Exclusive	BRCA spliceAI AF_1 Exclusive	0.52	1.69	1.27	0.67	0.62
BRCA spliceAI AF_1 Exclusive	Overlap	0.89	1.30	1933912382711348.00	0.89	1.45
somatic Exclusive	Overlap	1.00	1.33	57965738198663.00	1.76	1.92
Overlap	Exclusives	0.73	340618107534995.00	4.91	1.56	6.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA spliceAI AF_1 Exclusive	somatic	0.00	2.05	3.79	0.08	4.07
somatic Exclusive	BRCA spliceAI AF_1	0.00	0.73	7.00	1.82	2.95
BRCA spliceAI AF_1 Exclusive	somatic Exclusive	0.00	1.76	3.60	0.14	7.82
somatic Exclusive	BRCA spliceAI AF_1 Exclusive	0.00	0.14	3.71	0.32	0.33
BRCA spliceAI AF_1 Exclusive	Overlap	0.00	0.79	11023505737973312.00	0.09	0.23
somatic Exclusive	Overlap	0.01	6.90	71202483726573832.00	39.15	77.77
Overlap	Exclusives	0.02	2357601662162716.50	20.54	3.58	7.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA spliceAI AF_1 Exclusive	33	33	
somatic Exclusive	36	36	
Overlap	1	1