Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu-AD_male Exclusive	25-GS	1.03e-03	5.88e-05	2.82e-05	2.16e-06
25-GS Exclusive	mu-AD_male	8.34e-01	7.51e-01	1.39e-01	2.92e-01
mu-AD_male Exclusive	25-GS Exclusive	2.87e-03	4.05e-04	2.54e-04	2.64e-04
25-GS Exclusive	mu-AD_male Exclusive	8.33e-01	7.33e-01	2.19e-01	6.27e-01
mu-AD_male Exclusive	Overlap	9.63e-03	8.22e-02	6.18e-03	8.82e-04
25-GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	9.01e-04	1.25e-03	3.27e-13	9.21e-05



Evaluating how well mu-AD_male genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_male Exclusive	25-GS	0.80	2.16	5.16	2.73	4.83
25-GS Exclusive	mu-AD_male	0.55	1.51	1.08	1.54	1.38
mu-AD_male Exclusive	25-GS Exclusive	0.78	2.28	4.24	2.71	4.79
25-GS Exclusive	mu-AD_male Exclusive	0.53	0.95	0.71	0.93	0.92
mu-AD_male Exclusive	Overlap	0.97	2.43	2.31	2.09	2.57
25-GS Exclusive	Overlap	1.00	2.99	2.27	2.64	2.87
Overlap	Exclusives	0.63	3.18	4.51	2.51	3.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu-AD_male Exclusive	25-GS	0.01	1.67	10.07	5.42	6.54
25-GS Exclusive	mu-AD_male	0.01	14.28	4.93	7.10	15.68
mu-AD_male Exclusive	25-GS Exclusive	0.00	2.01	6.78	2.79	8.17
25-GS Exclusive	mu-AD_male Exclusive	0.01	5.42	0.82	5.26	4.97
mu-AD_male Exclusive	Overlap	0.00	5.47	7.96	4.02	7.00
25-GS Exclusive	Overlap	0.09	119.15	211.89	375.15	267.23
Overlap	Exclusives	0.05	51.51	28.19	42.58	27.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu-AD_male Exclusive	79	78	
25-GS Exclusive	22	21	HLA -DRB1
Overlap	3	3