Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA AF_001  Exclusive	somatic	6.75e-01	4.13e-01	5.43e-01	2.37e-10
somatic Exclusive	EA AF_001 	1.07e-04	7.73e-01	1.28e-12	5.86e-01
EA AF_001  Exclusive	somatic Exclusive	6.76e-01	3.25e-01	6.97e-01	9.07e-08
somatic Exclusive	EA AF_001  Exclusive	1.17e-04	7.46e-01	5.10e-13	7.12e-01
EA AF_001  Exclusive	Overlap	2.25e-01	4.13e-02	3.14e-01	2.05e-04
somatic Exclusive	Overlap	1.83e-09	4.67e-03	1.83e-09	2.30e-07
Overlap	Exclusives	3.78e-04	1.29e-02	2.45e-38	4.97e-03



Evaluating how well EA AF_001  genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_001  Exclusive	somatic	0.83	0.01	-1.04	-0.54	6.83
somatic Exclusive	EA AF_001 	0.52	-1.81	0.97	0.39	1.31
EA AF_001  Exclusive	somatic Exclusive	0.82	-0.24	-1.52	-0.88	5.95
somatic Exclusive	EA AF_001  Exclusive	0.52	-1.99	0.82	0.43	0.96
EA AF_001  Exclusive	Overlap	0.93	0.78	1.10	0.58	3.08
somatic Exclusive	Overlap	0.99	2.00	2.12	2.45	3.39
Overlap	Exclusives	0.56	0.35	2.04	1.06	3.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_001  Exclusive	somatic	0.02	0.08	-0.80	0.48	48.17
somatic Exclusive	EA AF_001 	0.02	-1.04	1.09	0.58	0.94
EA AF_001  Exclusive	somatic Exclusive	0.02	0.11	-1.30	0.34	46.51
somatic Exclusive	EA AF_001  Exclusive	0.01	-1.78	0.34	-0.05	-0.00
EA AF_001  Exclusive	Overlap	0.00	0.23	0.81	0.03	0.84
somatic Exclusive	Overlap	0.01	3.06	7.86	29.42	12.74
Overlap	Exclusives	0.02	2.51	5.27	3.75	6.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA AF_001  Exclusive	281	277	CBS;TEX52;C16orf86;AP000781.2
somatic Exclusive	33	33	
Overlap	4	4