Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_spliceAI AF_0001 Exclusive	somatic	1.45e-01	7.80e-01	5.30e-01	7.82e-10
somatic Exclusive	EA_spliceAI AF_0001	5.91e-03	2.40e-01	3.66e-14	6.34e-01
EA_spliceAI AF_0001 Exclusive	somatic Exclusive	2.25e-01	5.67e-01	3.16e-01	2.81e-08
somatic Exclusive	EA_spliceAI AF_0001 Exclusive	6.47e-03	3.98e-01	5.33e-16	8.59e-01
EA_spliceAI AF_0001 Exclusive	Overlap	5.03e-01	5.45e-01	7.54e-01	1.78e-03
somatic Exclusive	Overlap	1.83e-09	6.08e-03	1.83e-09	1.28e-07
Overlap	Exclusives	1.20e-03	2.85e-02	4.99e-50	2.07e-02



Evaluating how well EA_spliceAI AF_0001 genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_spliceAI AF_0001 Exclusive	somatic	0.83	0.93	-0.74	-0.39	6.93
somatic Exclusive	EA_spliceAI AF_0001	0.52	0.15	1.81	0.74	1.05
EA_spliceAI AF_0001 Exclusive	somatic Exclusive	0.82	0.61	-1.28	-0.58	6.90
somatic Exclusive	EA_spliceAI AF_0001 Exclusive	0.51	0.05	1.13	0.66	0.65
EA_spliceAI AF_0001 Exclusive	Overlap	0.92	1.06	1.22	0.17	2.93
somatic Exclusive	Overlap	0.99	1.99	2.27	2.51	3.38
Overlap	Exclusives	0.56	1.54	2.52	1.64	3.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_spliceAI AF_0001 Exclusive	somatic	0.02	0.97	0.84	0.83	45.33
somatic Exclusive	EA_spliceAI AF_0001	0.02	0.25	1.39	0.34	0.74
EA_spliceAI AF_0001 Exclusive	somatic Exclusive	0.03	0.86	0.62	0.61	26.68
somatic Exclusive	EA_spliceAI AF_0001 Exclusive	0.02	-0.47	0.49	-0.09	-0.27
EA_spliceAI AF_0001 Exclusive	Overlap	0.00	-0.05	0.51	-0.44	2.23
somatic Exclusive	Overlap	0.01	2.80	7.68	39.90	57.44
Overlap	Exclusives	0.02	3.91	4.60	2.99	5.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_spliceAI AF_0001 Exclusive	302	295	AP000781.2;C16orf86;RNASE4;TEX52;SPANXB1;CT45A3;CBS
somatic Exclusive	33	33	
Overlap	4	4