Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI AF_0001 Exclusive	somatic	3.87e-01	2.72e-01	6.23e-02	2.43e-10
somatic Exclusive	spliceAI AF_0001	3.52e-01	6.99e-01	4.32e-02	6.35e-01
spliceAI AF_0001 Exclusive	somatic Exclusive	2.52e-01	1.10e-01	3.20e-02	7.76e-10
somatic Exclusive	spliceAI AF_0001 Exclusive	3.21e-01	6.56e-01	5.91e-02	4.95e-01
spliceAI AF_0001 Exclusive	Overlap	3.76e-01	1.98e-02	4.16e-01	2.38e-01
somatic Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.70e-06	6.98e-09	8.29e-18	6.33e-16



Evaluating how well spliceAI AF_0001 genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_0001 Exclusive	somatic	0.72	-0.65	-1.48	-0.88	4.98
somatic Exclusive	spliceAI AF_0001	0.52	-0.15	-0.39	-0.22	0.28
spliceAI AF_0001 Exclusive	somatic Exclusive	0.72	-0.84	-1.89	-1.00	4.33
somatic Exclusive	spliceAI AF_0001 Exclusive	0.49	-0.12	-0.24	-0.68	-0.16
spliceAI AF_0001 Exclusive	Overlap	0.89	1.22	665542819816317.62	0.94	1.26
somatic Exclusive	Overlap	1.00	1.41	57965738198663.00	1.81	1.82
Overlap	Exclusives	0.80	72154857728931.33	4.51	1.74	6.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI AF_0001 Exclusive	somatic	0.00	-0.83	-1.64	-0.71	0.28
somatic Exclusive	spliceAI AF_0001	0.00	0.98	1.33	0.24	0.39
spliceAI AF_0001 Exclusive	somatic Exclusive	0.00	-0.90	-2.04	-0.86	1.26
somatic Exclusive	spliceAI AF_0001 Exclusive	0.00	-0.28	-0.59	-0.76	-0.52
spliceAI AF_0001 Exclusive	Overlap	0.00	0.21	inf	0.10	0.48
somatic Exclusive	Overlap	0.01	3.63	71202483726573832.00	28.17	32.46
Overlap	Exclusives	0.02	5367287375320512.00	3.90	3.50	21.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI AF_0001 Exclusive	17	17	
somatic Exclusive	36	36	
Overlap	1	1