Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
0 20	AD GWAS	4.73e-08	5.83e-09	2.63e-09	2.20e-10
AD GWAS	0 20	1.07e-01	9.93e-01	1.14e-01	2.73e-01



Evaluating how well 0 20 genes are linked to AD GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD GWAS	0.82	3.14	4.59	3.28	5.25
AD GWAS	0 20	0.53	0.64	0.12	0.44	1.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD GWAS	0.01	10.16	21.58	11.30	10.98
AD GWAS	0 20	0.01	10.56	11.73	4.52	7.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
0 20	128	126	AL162417.1;PRAMEF11
AD GWAS	25	25