Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
0 20	AD	1.23e-08	3.65e-09	4.89e-09	1.78e-09
AD	0 20	5.23e-01	7.91e-01	1.42e-01	4.96e-01



Evaluating how well 0 20 genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD	0.86	3.45	6.68	3.80	6.66
AD	0 20	0.52	0.56	0.41	0.47	0.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD	0.01	15.38	37.48	15.54	17.14
AD	0 20	0.02	17.04	24.08	13.47	21.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
0 20	75	74	AL162417.1
AD	25	25