Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
0 20	AD	8.23e-09	2.88e-09	2.20e-09	2.58e-10
AD	0 20	7.04e-01	5.77e-01	5.85e-02	1.68e-01



Evaluating how well 0 20 genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD	0.88	3.49	6.44	3.87	6.03
AD	0 20	0.54	0.59	0.50	0.60	0.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
0 20	AD	0.02	17.09	52.32	18.63	10.08
AD	0 20	0.02	40.71	28.22	16.92	8.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
0 20	50	49	AL162417.1
AD	25	25