Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
9K_mu_Z_35_male Exclusive	25GS	3.21e-02	2.53e-01	3.57e-02	5.79e-03
25GS Exclusive	9K_mu_Z_35_male	2.31e-01	5.36e-02	2.76e-02	3.63e-02
9K_mu_Z_35_male Exclusive	25GS Exclusive	9.80e-03	4.16e-02	2.39e-02	1.71e-02
25GS Exclusive	9K_mu_Z_35_male Exclusive	6.92e-01	2.01e-01	1.14e-01	2.14e-01
9K_mu_Z_35_male Exclusive	Overlap	8.69e-01	9.19e-01	9.48e-01	5.03e-01
25GS Exclusive	Overlap	3.84e-07	1.62e-05	2.74e-08	3.84e-07
Overlap	Exclusives	1.01e-02	1.83e-02	1.79e-11	7.79e-03



Evaluating how well 9K_mu_Z_35_male genes are linked to 25GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
9K_mu_Z_35_male Exclusive	25GS	0.72	2.27	2.07	1.45	3.60
25GS Exclusive	9K_mu_Z_35_male	0.57	2.03	2.73	2.10	2.47
9K_mu_Z_35_male Exclusive	25GS Exclusive	0.72	2.52	2.56	1.70	3.40
25GS Exclusive	9K_mu_Z_35_male Exclusive	0.55	1.72	1.57	1.70	1.59
9K_mu_Z_35_male Exclusive	Overlap	0.70	-0.49	-0.58	-0.30	1.27
25GS Exclusive	Overlap	0.99	2.79	3.05	2.76	3.66
Overlap	Exclusives	0.61	1.75	3.57	2.24	4.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
9K_mu_Z_35_male Exclusive	25GS	0.00	5.17	3.84	4.08	4.68
25GS Exclusive	9K_mu_Z_35_male	0.01	5.63	13.31	3.31	8.45
9K_mu_Z_35_male Exclusive	25GS Exclusive	0.00	6.16	3.50	2.33	2.04
25GS Exclusive	9K_mu_Z_35_male Exclusive	0.01	1.88	3.02	2.02	2.58
9K_mu_Z_35_male Exclusive	Overlap	0.00	0.38	-0.01	0.23	1.62
25GS Exclusive	Overlap	0.03	42.19	70.08	107.28	76.20
Overlap	Exclusives	0.02	16.39	32.82	18.97	9.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
9K_mu_Z_35_male Exclusive	74	71	;PRAMEF11;RFPL2
25GS Exclusive	21	20	HLA -DRB1
Overlap	4	4