Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI weighted	AD	8.62e-01	8.42e-01	8.07e-01	9.00e-02
AD	spliceAI weighted	6.23e-01	1.17e-01	5.49e-02	7.39e-02



Evaluating how well spliceAI weighted genes are linked to AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI weighted	AD	0.63	0.53	0.66	0.18	1.99
AD	spliceAI weighted	0.59	1.48	1.61	1.41	2.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI weighted	AD	0.00	0.48	0.42	0.04	1.53
AD	spliceAI weighted	0.00	0.58	0.89	-0.04	0.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI weighted	55	53	AL132671.2;AC010326.2
AD	25	25