Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial	3.07e-15	2.51e-13	4.57e-17	2.08e-18
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes	1.75e-10	4.60e-08	5.87e-11	1.35e-09
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	5.83e-08	9.96e-07	2.12e-09	7.30e-13
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	9.80e-07	4.12e-05	6.56e-07	8.80e-06
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	1.18e-16	1.84e-10	1.18e-16	4.23e-15
BRCA-familial Exclusive	Overlap	1.18e-16	1.18e-16	1.18e-16	9.41e-16
Overlap	Exclusives	4.53e-17	5.35e-15	7.30e-17	1.15e-15



Evaluating how well 12kDiscoCases_Clus0_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial	0.97	2.55	7.47	2.86	9.10
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes	0.73	1.95	3.94	2.33	7.49
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	0.96	2.47	5.08	3.04	7.31
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	0.70	1.63	3.62	2.16	5.46
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	1.00	2.12	5.03	2.23	4.52
BRCA-familial Exclusive	Overlap	1.00	2.49	4.34	2.63	4.72
Overlap	Exclusives	0.76	1.81	4.73	2.45	7.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial	0.18	60.91	241.61	108.19	289.83
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes	0.12	20.92	178.50	107.06	264.67
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	0.05	21.51	65.89	61.63	134.45
BRCA-familial Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	0.04	22.61	32.66	42.36	58.66
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	0.24	130.21	510.66	200.49	923.35
BRCA-familial Exclusive	Overlap	0.31	141.07	477.36	390.15	705.93
Overlap	Exclusives	0.07	20.87	101.91	40.66	148.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus0_10xGenes Exclusive	50	50	
BRCA-familial Exclusive	16	16	
Overlap	7	7