Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic	8.13e-02	5.05e-05	1.47e-08	1.46e-19
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes	2.28e-01	4.94e-02	4.11e-11	8.65e-06
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic Exclusive	3.68e-01	6.40e-05	2.83e-07	1.86e-17
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	5.41e-01	4.65e-02	6.25e-11	4.04e-05
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
BRCA-somatic Exclusive	Overlap	9.85e-05	1.18e-02	9.85e-05	9.85e-04
Overlap	Exclusives	1.22e-22	4.81e-18	7.72e-28	4.40e-26



Evaluating how well 12kDiscoCases_Clus0_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic	0.88	0.57	3.73	2.10	8.15
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes	0.69	0.29	2.33	1.80	4.41
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic Exclusive	0.87	0.25	3.49	2.05	7.63
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	0.68	0.24	2.41	1.71	4.96
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	1.00	1.48	2.61	1.65	2.32
BRCA-somatic Exclusive	Overlap	1.00	1.33	2.21	1.72	2.26
Overlap	Exclusives	0.81	5.98	6.72	2.38	11.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic	0.01	-0.61	4.81	2.69	17.54
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes	0.01	-0.19	3.58	2.21	10.54
12kDiscoCases_Clus0_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-0.93	2.63	1.48	7.96
BRCA-somatic Exclusive	12kDiscoCases_Clus0_10xGenes Exclusive	0.01	-0.48	1.38	2.82	4.46
12kDiscoCases_Clus0_10xGenes Exclusive	Overlap	0.02	10.38	200.30	38.84	35.53
BRCA-somatic Exclusive	Overlap	0.01	1.49	8.35	24.69	0.81
Overlap	Exclusives	0.05	20.10	56.88	9.70	21.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus0_10xGenes Exclusive	55	55	
BRCA-somatic Exclusive	35	35	
Overlap	2	2