Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial	7.15e-17	4.38e-11	9.02e-18	2.34e-20
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes	1.36e-05	2.64e-04	1.17e-14	4.30e-05
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial Exclusive	6.62e-11	6.21e-08	1.90e-11	1.15e-14
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	2.12e-05	5.11e-03	5.08e-14	1.10e-03
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	2.98e-14	6.26e-12	2.98e-14	3.69e-10
BRCA-familial Exclusive	Overlap	2.98e-14	2.98e-14	2.98e-14	8.35e-13
Overlap	Exclusives	2.43e-07	6.01e-07	6.28e-08	9.41e-08



Evaluating how well 12kDiscoCases_Clus1_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial	0.97	2.87	7.06	2.49	8.19
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes	0.62	1.47	3.15	0.93	5.03
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial Exclusive	0.96	2.72	6.11	2.33	7.09
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	0.60	1.17	1.71	0.44	3.60
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	0.99	3.20	3.94	2.49	4.68
BRCA-familial Exclusive	Overlap	1.00	3.05	4.26	2.80	4.25
Overlap	Exclusives	0.60	0.17	0.18	0.03	3.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial	0.02	2.19	43.25	8.46	27.05
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes	0.05	31.95	45.30	22.32	45.97
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-familial Exclusive	0.01	0.43	26.88	5.01	1.78
BRCA-familial Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	0.03	15.67	27.15	8.44	26.98
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	0.02	16.89	44.15	9.57	5.09
BRCA-familial Exclusive	Overlap	0.25	372.69	535.00	506.30	91.14
Overlap	Exclusives	0.06	17.31	72.65	17.21	73.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus1_10xGenes Exclusive	121	121	
BRCA-familial Exclusive	17	17	
Overlap	6	6