Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas	6.99e-07	8.80e-01	1.35e-03	2.01e-03
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes	6.62e-03	2.90e-01	1.81e-05	6.21e-02
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	4.59e-07	9.50e-01	4.07e-04	1.29e-03
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	3.21e-03	3.04e-01	3.10e-05	6.74e-02
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	5.17e-01	4.78e-01	5.17e-01	4.58e-02
BRCA-gwas Exclusive	Overlap	5.17e-01	9.17e-01	5.53e-02	1.87e-02
Overlap	Exclusives	2.17e-02	7.25e-04	1.41e-53	4.41e-06



Evaluating how well 12kDiscoCases_Clus1_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas	0.58	-0.68	0.12	-0.22	3.89
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes	0.56	-0.39	-0.15	-0.11	2.62
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	0.58	-0.94	-0.05	-0.62	3.34
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	0.55	-0.59	-0.41	0.02	1.93
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	0.92	0.91	1.14	0.62	2.28
BRCA-gwas Exclusive	Overlap	0.95	0.26	0.16	1.23	2.48
Overlap	Exclusives	0.60	0.75	0.49	0.51	5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas	0.01	-1.04	-0.14	-0.30	1.88
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes	0.01	1.18	3.02	1.53	2.21
12kDiscoCases_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.28	-0.40	-0.72	2.23
BRCA-gwas Exclusive	12kDiscoCases_Clus1_10xGenes Exclusive	0.01	0.09	2.25	0.53	2.21
12kDiscoCases_Clus1_10xGenes Exclusive	Overlap	0.00	0.77	7.42	1.12	1.33
BRCA-gwas Exclusive	Overlap	0.02	3.83	0.14	11.90	74.29
Overlap	Exclusives	0.03	4.22	15.25	4.85	16.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus1_10xGenes Exclusive	125	125	
BRCA-gwas Exclusive	171	171	
Overlap	2	2