Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas	1.20e-06	5.65e-01	5.55e-04	2.84e-06
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes	1.16e-01	6.09e-01	9.31e-13	6.17e-09
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	9.76e-07	8.40e-01	2.45e-03	5.61e-05
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes Exclusive	1.36e-01	6.41e-01	8.92e-11	2.64e-08
12kDiscoCases_Clus2_10xGenes Exclusive	Overlap	7.14e-03	7.85e-03	2.10e-07	1.66e-06
BRCA-gwas Exclusive	Overlap	1.92e-02	7.47e-02	4.84e-08	1.21e-06
Overlap	Exclusives	8.58e-13	8.60e-10	4.70e-42	2.84e-24



Evaluating how well 12kDiscoCases_Clus2_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas	0.61	-1.09	-0.01	0.40	5.52
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes	0.63	-0.58	0.72	0.95	7.22
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	0.60	-1.28	-0.46	0.06	4.22
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes Exclusive	0.62	-0.46	0.57	0.58	6.57
12kDiscoCases_Clus2_10xGenes Exclusive	Overlap	0.95	2.08	2.72	2.25	4.09
BRCA-gwas Exclusive	Overlap	0.97	1.66	2.12	2.62	3.80
Overlap	Exclusives	0.68	2.64	7.45	2.08	13.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas	0.01	-2.35	1.03	0.43	7.28
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes	0.02	-0.60	1.52	1.38	8.15
12kDiscoCases_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-2.80	-0.41	-0.44	3.05
BRCA-gwas Exclusive	12kDiscoCases_Clus2_10xGenes Exclusive	0.02	-0.78	0.24	0.60	4.48
12kDiscoCases_Clus2_10xGenes Exclusive	Overlap	0.01	8.25	51.22	16.76	59.15
BRCA-gwas Exclusive	Overlap	0.01	3.31	0.92	19.65	15.12
Overlap	Exclusives	0.08	16.21	45.84	15.73	61.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus2_10xGenes Exclusive	226	225	UGT2A1
BRCA-gwas Exclusive	167	167	
Overlap	6	6