Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial	4.33e-15	1.84e-12	1.18e-18	1.31e-19
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes	4.07e-07	1.99e-05	8.81e-29	3.73e-07
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	2.82e-05	1.32e-04	2.40e-08	8.06e-11
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	7.40e-05	1.17e-03	8.45e-32	1.11e-06
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	6.87e-24	7.06e-14	6.87e-24	1.26e-15
BRCA-familial Exclusive	Overlap	6.87e-24	6.87e-24	6.87e-24	4.53e-22
Overlap	Exclusives	2.56e-10	1.91e-06	6.07e-08	1.76e-06



Evaluating how well 12kDiscoCases_Clus3_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial	0.97	3.92	7.77	2.79	8.75
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes	0.65	1.83	3.98	1.15	6.69
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	0.96	2.80	4.33	2.95	5.51
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	0.63	1.87	2.88	0.94	5.96
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	0.99	3.38	5.91	2.57	5.67
BRCA-familial Exclusive	Overlap	1.00	3.44	4.58	3.38	4.95
Overlap	Exclusives	0.61	0.71	1.04	0.20	5.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial	0.04	2.19	33.55	14.39	124.18
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes	0.09	41.49	133.41	37.34	97.61
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	0.01	-0.33	14.75	3.31	22.07
BRCA-familial Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	0.04	19.87	48.39	15.88	45.38
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	0.04	23.83	15.83	17.62	68.83
BRCA-familial Exclusive	Overlap	0.33	167.30	601.66	369.48	1178.06
Overlap	Exclusives	0.07	13.67	67.73	24.92	79.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus3_10xGenes Exclusive	183	183	
BRCA-familial Exclusive	13	13	
Overlap	10	10