Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic	5.27e-02	2.71e-01	2.31e-03	4.60e-10
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes	1.41e-03	4.31e-01	1.38e-12	5.89e-05
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic Exclusive	1.44e-02	5.44e-01	1.43e-02	1.67e-09
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	6.67e-04	5.23e-01	2.11e-11	2.48e-05
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
BRCA-somatic Exclusive	Overlap	9.85e-05	8.97e-03	9.85e-05	9.85e-05
Overlap	Exclusives	1.25e-13	2.09e-10	1.45e-36	1.83e-14



Evaluating how well 12kDiscoCases_Clus3_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic	0.81	-1.73	1.54	-0.41	7.52
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes	0.60	1.21	0.64	0.43	4.59
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic Exclusive	0.80	-2.57	1.37	-0.64	7.72
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	0.59	1.15	0.45	-0.01	4.74
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	1.00	1.57	2.27	1.41	2.60
BRCA-somatic Exclusive	Overlap	1.00	1.43	2.53	1.78	2.76
Overlap	Exclusives	0.67	0.47	3.45	0.87	8.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic	0.01	-1.74	3.59	-0.99	14.53
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes	0.01	-0.16	0.69	0.54	2.30
12kDiscoCases_Clus3_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.99	1.58	-1.30	9.60
BRCA-somatic Exclusive	12kDiscoCases_Clus3_10xGenes Exclusive	0.01	-0.05	-0.03	0.01	3.41
12kDiscoCases_Clus3_10xGenes Exclusive	Overlap	0.02	10.16	98.76	14.57	60.63
BRCA-somatic Exclusive	Overlap	0.01	1.46	9.23	26.23	49.44
Overlap	Exclusives	0.06	17.00	51.58	10.39	59.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus3_10xGenes Exclusive	191	191	
BRCA-somatic Exclusive	35	35	
Overlap	2	2