Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial	3.07e-15	1.10e-13	6.03e-20	2.48e-22
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes	5.28e-14	8.63e-13	5.46e-26	1.08e-12
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial Exclusive	8.43e-05	2.82e-05	3.61e-08	9.94e-11
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	7.58e-09	4.54e-08	4.79e-25	8.38e-08
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	4.45e-13	1.36e-10	1.11e-18	9.75e-15
BRCA-familial Exclusive	Overlap	2.96e-23	4.81e-14	1.31e-27	5.23e-21
Overlap	Exclusives	2.60e-14	3.30e-12	1.51e-14	1.25e-12



Evaluating how well 12kDiscoCases_Clus4_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial	0.98	3.46	8.31	2.87	7.82
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes	0.70	3.01	5.00	1.45	8.24
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial Exclusive	0.97	3.56	4.60	2.94	5.36
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	0.68	2.43	4.46	1.60	7.67
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	0.99	2.76	6.24	2.40	6.05
BRCA-familial Exclusive	Overlap	1.00	5.92	4.83	2.68	6.23
Overlap	Exclusives	0.69	1.41	5.05	1.68	8.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial	0.06	3.44	91.84	33.31	66.51
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes	0.15	51.81	188.98	44.47	205.22
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-familial Exclusive	0.02	-0.29	25.58	6.74	38.28
BRCA-familial Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	0.07	23.63	95.23	28.61	108.01
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	0.06	20.65	92.17	17.27	66.02
BRCA-familial Exclusive	Overlap	0.29	290.64	417.81	232.89	1170.02
Overlap	Exclusives	0.11	18.88	154.66	47.54	165.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus4_10xGenes Exclusive	138	137	UGT2A1
BRCA-familial Exclusive	11	11	
Overlap	12	12