Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic	3.39e-02	1.44e-01	1.04e-02	2.13e-17
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes	7.50e-02	8.15e-01	6.36e-12	2.79e-05
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic Exclusive	8.72e-03	1.29e-01	1.68e-01	7.59e-15
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	4.64e-02	6.75e-01	6.88e-10	6.46e-05
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	1.93e-01	1.77e-01	1.94e-05	4.34e-05
BRCA-somatic Exclusive	Overlap	1.83e-09	1.34e-05	1.83e-09	3.84e-07
Overlap	Exclusives	9.60e-16	2.86e-15	2.35e-56	1.05e-26



Evaluating how well 12kDiscoCases_Clus4_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic	0.85	-0.23	1.74	1.11	6.91
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes	0.63	0.16	0.91	0.81	5.80
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic Exclusive	0.83	-0.54	1.59	0.81	6.70
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	0.62	0.08	0.99	0.54	5.13
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	0.97	0.72	2.49	1.20	3.10
BRCA-somatic Exclusive	Overlap	0.99	1.38	2.53	2.35	3.38
Overlap	Exclusives	0.75	1.63	7.54	2.11	12.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic	0.01	-1.61	1.24	-0.33	14.69
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes	0.01	-0.55	0.98	1.25	6.42
12kDiscoCases_Clus4_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.82	0.02	-0.95	5.63
BRCA-somatic Exclusive	12kDiscoCases_Clus4_10xGenes Exclusive	0.01	-0.56	0.22	0.40	1.89
12kDiscoCases_Clus4_10xGenes Exclusive	Overlap	0.01	-0.17	13.41	4.54	30.41
BRCA-somatic Exclusive	Overlap	0.02	1.10	14.14	18.50	11.45
Overlap	Exclusives	0.08	12.06	72.45	23.41	75.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus4_10xGenes Exclusive	146	145	UGT2A1
BRCA-somatic Exclusive	33	33	
Overlap	4	4