Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial	6.78e-16	6.89e-13	7.29e-27	3.72e-24
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes	8.63e-07	3.68e-05	5.99e-21	1.18e-13
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial Exclusive	6.48e-08	1.47e-06	2.47e-15	5.25e-16
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	3.30e-04	3.42e-03	2.10e-17	1.01e-11
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	4.60e-19	2.69e-12	4.60e-19	2.25e-13
BRCA-familial Exclusive	Overlap	4.60e-19	4.60e-19	4.60e-19	4.14e-18
Overlap	Exclusives	2.04e-08	1.13e-06	1.22e-08	4.00e-13



Evaluating how well 12kDiscoCases_Clus5_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial	0.99	2.29	6.07	2.86	7.62
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes	0.74	2.12	5.30	2.72	9.57
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial Exclusive	0.98	2.24	4.68	2.68	6.13
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.72	1.98	3.64	2.12	8.73
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	1.00	2.73	4.61	2.78	5.44
BRCA-familial Exclusive	Overlap	1.00	2.61	5.31	2.98	4.89
Overlap	Exclusives	0.71	0.57	3.45	1.53	8.35

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial	0.22	17.77	256.24	104.01	812.02
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes	0.09	42.00	88.05	43.66	112.74
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-familial Exclusive	0.04	0.73	50.81	19.53	53.87
BRCA-familial Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.04	19.41	30.95	19.28	52.45
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	0.32	254.32	795.53	623.26	533.49
BRCA-familial Exclusive	Overlap	0.29	411.48	599.44	461.53	957.77
Overlap	Exclusives	0.08	21.04	87.97	39.23	98.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus5_10xGenes Exclusive	126	126	
BRCA-familial Exclusive	15	15	
Overlap	8	8