Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic	1.71e-02	2.83e-01	1.07e-06	6.94e-14
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes	6.75e-02	1.25e-03	1.41e-27	1.17e-15
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic Exclusive	8.39e-02	6.92e-01	6.69e-06	1.21e-12
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	1.50e-01	1.01e-03	6.33e-26	1.31e-14
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
BRCA-somatic Exclusive	Overlap	9.85e-05	2.28e-02	9.85e-05	9.85e-05
Overlap	Exclusives	3.26e-13	5.73e-12	4.27e-46	1.27e-24



Evaluating how well 12kDiscoCases_Clus5_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic	0.86	-1.32	1.31	1.14	7.30
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes	0.71	0.05	3.25	2.50	8.92
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic Exclusive	0.85	-1.38	1.01	1.13	7.15
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.70	0.02	3.40	2.44	7.60
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	1.00	1.38	1.73	1.58	2.38
BRCA-somatic Exclusive	Overlap	1.00	1.16	2.30	1.96	2.24
Overlap	Exclusives	0.77	2.26	6.06	2.10	11.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic	0.01	-2.11	3.86	1.27	32.41
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes	0.01	-0.65	2.02	3.47	10.33
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-2.47	1.00	0.44	11.20
BRCA-somatic Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.01	-0.93	1.68	3.37	9.77
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	0.03	8.05	117.89	24.59	116.42
BRCA-somatic Exclusive	Overlap	0.01	0.89	7.21	34.06	34.68
Overlap	Exclusives	0.06	20.33	50.90	14.74	77.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus5_10xGenes Exclusive	132	132	
BRCA-somatic Exclusive	35	35	
Overlap	2	2