Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas	4.90e-03	2.57e-01	4.97e-08	2.26e-05
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes	2.37e-01	2.20e-01	7.64e-11	4.49e-11
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas Exclusive	6.26e-03	6.45e-01	8.10e-07	1.63e-04
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	4.75e-01	2.34e-01	3.94e-11	5.97e-11
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	6.40e-08
BRCA-gwas Exclusive	Overlap	1.44e-01	1.41e-01	1.16e-03	2.61e-03
Overlap	Exclusives	9.27e-08	2.50e-07	1.09e-47	1.65e-29



Evaluating how well 12kDiscoCases_Clus5_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas	0.62	-0.57	0.82	1.14	5.42
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes	0.70	0.55	2.79	1.69	8.20
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas Exclusive	0.61	-0.60	0.03	0.97	4.58
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.69	0.32	2.81	1.91	7.81
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	0.99	2.70	3.52	2.92	3.33
BRCA-gwas Exclusive	Overlap	0.92	2.61	3.11	2.27	3.48
Overlap	Exclusives	0.72	3.39	7.90	2.94	13.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas	0.02	-1.22	4.51	2.77	7.03
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes	0.01	0.08	1.99	1.80	10.55
12kDiscoCases_Clus5_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.63	0.87	1.47	4.86
BRCA-gwas Exclusive	12kDiscoCases_Clus5_10xGenes Exclusive	0.01	-0.13	1.67	2.20	4.85
12kDiscoCases_Clus5_10xGenes Exclusive	Overlap	0.03	23.09	73.89	75.79	48.41
BRCA-gwas Exclusive	Overlap	0.00	1.76	2.91	2.52	0.41
Overlap	Exclusives	0.05	13.05	33.17	11.63	38.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_Clus5_10xGenes Exclusive	130	130	
BRCA-gwas Exclusive	169	169	
Overlap	4	4