Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial	3.74e-15	2.43e-11	2.37e-23	4.21e-20
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes	1.88e-06	5.61e-05	2.64e-16	5.24e-12
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	1.02e-11	1.92e-08	3.65e-19	9.23e-19
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	3.08e-05	1.19e-04	1.74e-14	6.56e-11
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	5.23e-05
BRCA-familial Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.56e-09	1.27e-07	6.66e-24	3.61e-16



Evaluating how well 12kDiscoControls_Clus0_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial	0.97	2.91	6.14	2.69	7.84
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes	0.73	1.18	4.20	2.75	9.86
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	0.97	2.58	5.60	2.80	6.98
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	0.73	0.98	4.41	1.83	7.95
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	0.98	1.39	3.63	1.80	2.72
BRCA-familial Exclusive	Overlap	1.00	1.71	2.58	2.44	3.03
Overlap	Exclusives	0.75	5.06	4.98	1.56	10.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial	0.02	0.01	17.18	6.81	34.20
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes	0.03	3.09	20.16	13.01	32.47
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-familial Exclusive	0.02	-0.37	11.89	8.69	22.44
BRCA-familial Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	0.02	2.08	17.18	7.27	13.59
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	0.00	2.17	30.23	4.61	16.56
BRCA-familial Exclusive	Overlap	0.03	15.79	95.23	97.86	50.03
Overlap	Exclusives	0.05	36.90	45.16	11.65	34.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus0_10xGenes Exclusive	118	118	
BRCA-familial Exclusive	20	20	
Overlap	3	3