Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus0_10xGenes	BRCA-somatic	4.63e-03	2.98e-02	4.00e-14	1.99e-18
BRCA-somatic	12kDiscoControls_Clus0_10xGenes	1.51e-04	6.31e-05	9.80e-25	4.67e-13



Evaluating how well 12kDiscoControls_Clus0_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes	BRCA-somatic	0.89	-0.75	2.90	1.93	7.04
BRCA-somatic	12kDiscoControls_Clus0_10xGenes	0.73	1.14	4.46	2.55	7.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes	BRCA-somatic	0.02	-1.87	5.84	1.81	27.83
BRCA-somatic	12kDiscoControls_Clus0_10xGenes	0.02	-0.51	4.17	5.86	7.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus0_10xGenes	121	121	
BRCA-somatic	37	37