Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas	3.16e-02	8.70e-02	8.06e-06	4.18e-08
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes	1.61e-02	3.86e-02	5.99e-11	6.73e-09
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas Exclusive	2.34e-02	1.42e-01	1.12e-05	6.11e-08
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	7.17e-03	7.39e-02	5.46e-10	2.90e-08
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
BRCA-gwas Exclusive	Overlap	3.96e-01	4.36e-01	1.98e-02	3.96e-02
Overlap	Exclusives	4.44e-03	1.83e-03	1.90e-35	1.40e-17



Evaluating how well 12kDiscoControls_Clus0_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas	0.63	-0.01	1.43	1.59	5.15
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes	0.69	-0.32	1.60	1.19	6.77
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas Exclusive	0.63	-0.07	1.16	1.56	5.63
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	0.68	-0.18	1.79	0.97	7.17
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	1.00	1.38	1.08	1.22	1.82
BRCA-gwas Exclusive	Overlap	0.94	0.42	1.14	0.82	1.82
Overlap	Exclusives	0.67	1.37	5.00	1.54	10.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas	0.02	-1.48	1.34	2.15	6.88
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes	0.02	-0.30	2.62	2.98	9.46
12kDiscoControls_Clus0_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.71	1.27	1.37	5.24
BRCA-gwas Exclusive	12kDiscoControls_Clus0_10xGenes Exclusive	0.02	-0.05	2.60	2.39	8.88
12kDiscoControls_Clus0_10xGenes Exclusive	Overlap	0.01	2.95	18.73	4.38	32.54
BRCA-gwas Exclusive	Overlap	0.00	-0.28	0.34	0.28	1.89
Overlap	Exclusives	0.03	2.73	10.35	2.30	17.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus0_10xGenes Exclusive	120	120	
BRCA-gwas Exclusive	172	172	
Overlap	1	1