Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic	2.32e-02	1.52e-01	8.04e-05	1.26e-14
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes	1.46e-04	1.77e-02	2.22e-17	2.61e-07
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic Exclusive	1.31e-02	1.62e-01	1.19e-04	1.38e-15
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	3.58e-04	9.27e-03	8.10e-18	1.36e-06
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	6.77e-01	6.44e-01	7.79e-01	1.63e-01
BRCA-somatic Exclusive	Overlap	5.17e-01	5.17e-01	8.08e-02	9.32e-02
Overlap	Exclusives	6.80e-02	3.82e-01	2.20e-15	2.53e-10



Evaluating how well 12kDiscoControls_Clus1_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic	0.86	-0.41	2.72	1.11	6.72
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes	0.63	0.42	1.10	0.36	5.73
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic Exclusive	0.87	-0.64	2.90	0.99	7.24
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	0.62	0.31	0.97	0.72	5.08
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	0.76	0.43	1.04	0.75	1.41
BRCA-somatic Exclusive	Overlap	0.89	-0.49	1.51	1.80	1.97
Overlap	Exclusives	0.64	1.30	0.43	-0.09	7.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic	0.01	-1.78	4.25	-0.32	14.33
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes	0.02	1.03	5.24	1.73	10.47
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.91	4.88	-0.24	12.16
BRCA-somatic Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	0.02	0.35	4.34	3.41	7.78
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	0.00	-0.41	0.05	-0.52	0.63
BRCA-somatic Exclusive	Overlap	0.01	1.59	66.35	26.04	22.11
Overlap	Exclusives	0.02	2.28	1.45	-0.08	9.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus1_10xGenes Exclusive	179	178	PNLIPRP2
BRCA-somatic Exclusive	35	35	
Overlap	2	2