Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas	1.87e-04	8.30e-01	1.04e-02	1.09e-03
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes	1.58e-04	6.05e-02	1.21e-08	1.11e-05
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	1.28e-04	8.17e-01	1.22e-02	9.60e-04
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	1.63e-04	7.28e-02	2.77e-09	2.04e-05
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	1.98e-02	3.37e-01	1.98e-02	1.39e-01
BRCA-gwas Exclusive	Overlap	4.55e-01	4.55e-01	3.96e-02	1.58e-01
Overlap	Exclusives	1.51e-01	3.16e-01	6.38e-30	1.87e-11



Evaluating how well 12kDiscoControls_Clus1_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas	0.59	-1.79	-0.61	-0.58	4.17
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes	0.59	-1.63	-1.78	-0.41	4.49
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	0.58	-1.92	-0.68	-0.56	3.59
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	0.59	-1.59	-1.33	-0.23	4.36
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	0.97	1.06	1.05	1.06	1.61
BRCA-gwas Exclusive	Overlap	0.94	0.36	1.13	0.86	1.42
Overlap	Exclusives	0.62	0.11	1.78	0.44	8.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas	0.01	-2.44	-1.03	-0.69	3.11
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes	0.01	-1.19	0.90	0.42	5.34
12kDiscoControls_Clus1_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-2.26	-0.92	-0.92	3.03
BRCA-gwas Exclusive	12kDiscoControls_Clus1_10xGenes Exclusive	0.01	-1.00	0.62	0.48	4.76
12kDiscoControls_Clus1_10xGenes Exclusive	Overlap	0.00	0.12	0.29	1.65	0.60
BRCA-gwas Exclusive	Overlap	0.00	-0.23	0.33	0.13	0.74
Overlap	Exclusives	0.03	0.40	3.52	0.77	11.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus1_10xGenes Exclusive	180	179	PNLIPRP2
BRCA-gwas Exclusive	172	172	
Overlap	1	1