Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial	3.25e-06	9.44e-08	4.11e-10	8.82e-14
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes	3.76e-03	4.11e-01	3.33e-09	1.42e-05
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial Exclusive	2.20e-05	1.58e-06	6.59e-09	4.55e-12
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	3.60e-03	5.20e-01	1.17e-09	8.89e-06
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	5.42e-03	9.85e-05	9.85e-05	5.42e-03
BRCA-familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	4.40e-05	1.20e-03	2.23e-18	1.13e-07



Evaluating how well 12kDiscoControls_Clus2_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial	0.90	1.63	5.45	1.33	8.09
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes	0.62	1.52	1.25	0.68	4.61
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial Exclusive	0.90	1.55	4.74	1.61	6.06
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	0.62	1.43	1.04	0.68	4.79
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	0.92	0.90	5.17	1.12	2.14
BRCA-familial Exclusive	Overlap	1.00	1.64	2.05	2.17	2.57
Overlap	Exclusives	0.66	5.18	2.04	0.91	5.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial	0.01	-0.52	6.59	0.38	9.32
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes	0.01	2.89	3.48	1.56	4.48
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-familial Exclusive	0.01	-0.54	6.01	0.42	2.35
BRCA-familial Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	0.01	1.71	2.30	1.16	4.87
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	0.00	-0.09	15.94	0.51	3.48
BRCA-familial Exclusive	Overlap	0.02	21.95	77.85	88.73	52.39
Overlap	Exclusives	0.03	42.40	27.92	7.98	24.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus2_10xGenes Exclusive	121	121	
BRCA-familial Exclusive	21	21	
Overlap	2	2