Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas	5.24e-03	5.50e-01	8.28e-03	9.11e-06
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes	1.08e-01	9.40e-01	2.00e-04	2.20e-03
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	5.72e-03	4.79e-01	1.43e-02	1.95e-05
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	1.82e-01	9.06e-01	2.82e-04	2.48e-03
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	9.90e-02	9.31e-01	3.96e-02	7.92e-02
BRCA-gwas Exclusive	Overlap	4.75e-01	2.38e-01	3.96e-02	1.58e-01
Overlap	Exclusives	7.87e-01	5.21e-02	1.48e-34	2.41e-10



Evaluating how well 12kDiscoControls_Clus2_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas	0.61	-0.13	1.12	0.75	5.02
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes	0.59	-0.22	0.25	0.33	3.75
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	0.60	-0.10	0.89	0.52	4.60
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	0.59	0.07	0.36	0.30	3.27
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	0.94	0.68	0.66	0.84	1.56
BRCA-gwas Exclusive	Overlap	0.94	0.43	1.50	0.98	1.45
Overlap	Exclusives	0.63	0.60	3.35	1.12	9.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas	0.01	-0.93	1.44	0.57	2.78
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes	0.01	-0.45	0.35	0.38	1.55
12kDiscoControls_Clus2_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-0.94	1.00	0.33	5.04
BRCA-gwas Exclusive	12kDiscoControls_Clus2_10xGenes Exclusive	0.01	-0.23	0.55	0.39	1.57
12kDiscoControls_Clus2_10xGenes Exclusive	Overlap	0.00	-0.18	-0.62	0.04	0.80
BRCA-gwas Exclusive	Overlap	0.00	-0.23	0.76	0.43	0.66
Overlap	Exclusives	0.02	0.27	2.99	0.97	8.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus2_10xGenes Exclusive	122	122	
BRCA-gwas Exclusive	172	172	
Overlap	1	1