Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial	5.90e-01	6.61e-02	9.73e-03	6.50e-09
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes	1.83e-02	3.71e-02	4.51e-13	3.10e-09
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	6.27e-01	2.30e-01	1.08e-02	6.95e-07
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	2.83e-02	5.18e-02	2.71e-12	7.45e-09
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	2.47e-01	1.01e-01	6.56e-01	5.17e-03
BRCA-familial Exclusive	Overlap	7.45e-12	7.45e-12	7.45e-12	4.47e-11
Overlap	Exclusives	1.30e-02	7.73e-02	1.00e-13	1.42e-06



Evaluating how well 12kDiscoControls_Clus3_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial	0.82	0.32	2.67	0.69	5.86
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes	0.66	0.95	3.55	0.96	7.65
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	0.83	0.29	2.05	0.73	4.93
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	0.65	0.82	2.69	0.84	6.50
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	0.80	-0.07	1.54	0.30	2.03
BRCA-familial Exclusive	Overlap	1.00	2.49	3.49	3.15	3.83
Overlap	Exclusives	0.64	2.10	1.15	0.30	6.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial	0.00	-0.83	0.20	-0.42	5.43
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes	0.02	0.58	6.53	2.05	10.66
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-familial Exclusive	0.00	-0.85	0.22	-0.60	6.12
BRCA-familial Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	0.01	-0.23	1.62	0.56	2.35
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	0.00	-0.50	0.90	-0.37	0.26
BRCA-familial Exclusive	Overlap	0.06	29.62	168.86	164.21	148.10
Overlap	Exclusives	0.03	11.18	16.32	3.81	14.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus3_10xGenes Exclusive	146	146	
BRCA-familial Exclusive	18	18	
Overlap	5	5