Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus3_10xGenes	BRCA-somatic	1.47e-02	3.96e-02	2.57e-05	1.43e-11
BRCA-somatic	12kDiscoControls_Clus3_10xGenes	3.50e-04	4.25e-02	8.20e-13	3.86e-07



Evaluating how well 12kDiscoControls_Clus3_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes	BRCA-somatic	0.85	-0.19	3.68	1.12	7.33
BRCA-somatic	12kDiscoControls_Clus3_10xGenes	0.64	1.69	2.69	1.02	5.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes	BRCA-somatic	0.01	-1.71	3.93	-0.13	11.38
BRCA-somatic	12kDiscoControls_Clus3_10xGenes	0.01	0.99	5.33	2.12	5.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus3_10xGenes	151	151	
BRCA-somatic	37	37