Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas	5.77e-07	9.55e-01	1.26e-04	2.59e-03
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes	5.24e-04	2.68e-01	1.16e-05	6.22e-03
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas Exclusive	3.75e-07	9.82e-01	5.97e-04	5.37e-03
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	1.37e-03	1.99e-01	1.54e-05	5.63e-03
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	7.19e-05	6.61e-03	4.36e-07	2.96e-04
BRCA-gwas Exclusive	Overlap	7.89e-01	9.55e-01	7.89e-01	2.82e-01
Overlap	Exclusives	1.67e-03	2.97e-03	2.59e-69	8.94e-18



Evaluating how well 12kDiscoControls_Clus3_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas	0.60	-0.86	0.09	-0.07	4.24
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes	0.59	-1.23	-0.85	0.10	3.67
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas Exclusive	0.59	-0.81	-0.03	-0.14	4.09
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	0.59	-1.14	-0.84	-0.02	4.29
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	0.95	2.30	2.08	2.29	2.76
BRCA-gwas Exclusive	Overlap	0.76	-1.10	-1.24	-0.34	1.82
Overlap	Exclusives	0.67	1.41	5.27	1.49	10.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas	0.01	-1.54	-0.49	-0.34	4.26
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes	0.01	-1.06	-0.00	0.41	3.79
12kDiscoControls_Clus3_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.60	-0.69	-0.57	2.34
BRCA-gwas Exclusive	12kDiscoControls_Clus3_10xGenes Exclusive	0.01	-1.05	0.09	0.13	4.10
12kDiscoControls_Clus3_10xGenes Exclusive	Overlap	0.00	-0.09	6.90	2.07	2.30
BRCA-gwas Exclusive	Overlap	0.01	2.77	-0.17	21.83	33.91
Overlap	Exclusives	0.03	2.63	9.00	2.62	16.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus3_10xGenes Exclusive	148	148	
BRCA-gwas Exclusive	170	170	
Overlap	3	3