Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus4_10xGenes	BRCA-familial	1.10e-05	2.78e-07	6.14e-10	6.43e-16
BRCA-familial	12kDiscoControls_Clus4_10xGenes	5.88e-14	3.79e-01	2.53e-12	4.59e-05



Evaluating how well 12kDiscoControls_Clus4_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus4_10xGenes	BRCA-familial	0.91	1.16	4.76	1.42	6.79
BRCA-familial	12kDiscoControls_Clus4_10xGenes	0.57	0.02	-1.27	-0.21	4.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus4_10xGenes	BRCA-familial	0.01	-1.23	4.51	-0.49	8.76
BRCA-familial	12kDiscoControls_Clus4_10xGenes	0.02	1.92	2.54	0.99	7.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus4_10xGenes	266	266	
BRCA-familial	23	23