Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas	3.08e-09	2.70e-01	1.50e-03	3.89e-04
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes	3.61e-11	1.30e-05	5.52e-02	1.09e-02
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas Exclusive	3.74e-09	1.33e-01	9.95e-04	1.72e-03
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes Exclusive	7.42e-11	8.07e-06	2.90e-02	1.88e-02
12kDiscoControls_Clus4_10xGenes Exclusive	Overlap	1.78e-01	6.34e-01	1.39e-01	1.98e-01
BRCA-gwas Exclusive	Overlap	1.19e-01	5.94e-02	1.98e-02	7.92e-02
Overlap	Exclusives	1.62e-13	7.22e-10	2.16e-31	8.03e-26



Evaluating how well 12kDiscoControls_Clus4_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas	0.57	-3.07	-0.96	-1.70	3.27
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes	0.52	-2.57	-4.74	-1.63	0.99
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas Exclusive	0.57	-2.96	-1.45	-1.80	3.89
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes Exclusive	0.52	-2.41	-4.96	-1.37	0.85
12kDiscoControls_Clus4_10xGenes Exclusive	Overlap	0.85	1.37	0.87	1.27	1.36
BRCA-gwas Exclusive	Overlap	0.95	1.39	1.68	1.83	1.59
Overlap	Exclusives	0.66	1.05	6.48	1.69	12.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas	0.01	-3.03	-1.67	-2.09	1.14
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes	0.01	-1.97	-3.19	-1.18	0.03
12kDiscoControls_Clus4_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-3.38	-2.19	-2.22	1.29
BRCA-gwas Exclusive	12kDiscoControls_Clus4_10xGenes Exclusive	0.01	-1.73	-3.21	-0.97	0.06
12kDiscoControls_Clus4_10xGenes Exclusive	Overlap	0.00	1.03	-0.20	0.43	0.43
BRCA-gwas Exclusive	Overlap	0.00	0.78	3.34	2.97	0.08
Overlap	Exclusives	0.04	0.93	7.21	1.96	15.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus4_10xGenes Exclusive	265	265	
BRCA-gwas Exclusive	172	172	
Overlap	1	1