Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-familial	6.43e-01	6.08e-01	2.41e-02	1.36e-06
BRCA-familial	12kDiscoControls_Clus5_10xGenes	1.30e-04	4.22e-01	9.36e-05	7.17e-04



Evaluating how well 12kDiscoControls_Clus5_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-familial	0.79	-0.51	0.90	0.47	4.59
BRCA-familial	12kDiscoControls_Clus5_10xGenes	0.62	-0.67	-0.12	0.30	4.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-familial	0.00	-0.78	-0.52	-0.05	2.44
BRCA-familial	12kDiscoControls_Clus5_10xGenes	0.01	-0.36	0.78	0.99	3.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus5_10xGenes	96	96	
BRCA-familial	23	23