Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-gwas	2.25e-02	7.68e-01	2.20e-04	5.40e-05
BRCA-gwas	12kDiscoControls_Clus5_10xGenes	8.88e-03	2.38e-01	2.39e-05	5.52e-03



Evaluating how well 12kDiscoControls_Clus5_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-gwas	0.61	-0.49	0.92	0.80	5.05
BRCA-gwas	12kDiscoControls_Clus5_10xGenes	0.60	-1.11	-1.07	0.01	3.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_Clus5_10xGenes	BRCA-gwas	0.01	-1.15	0.02	0.97	5.61
BRCA-gwas	12kDiscoControls_Clus5_10xGenes	0.01	1.22	4.86	3.28	8.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_Clus5_10xGenes	96	96	
BRCA-gwas	173	173