Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes	BRCA-familial	6.11e-01	5.05e-01	3.45e-02	1.91e-06
BRCA-familial	12kDiscoControls_10xGenes	1.03e-04	4.90e-01	4.20e-05	1.04e-03



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes	BRCA-familial	0.79	-0.49	1.04	0.45	4.81
BRCA-familial	12kDiscoControls_10xGenes	0.62	-0.61	-0.16	0.35	4.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes	BRCA-familial	0.00	-0.78	-0.55	-0.13	1.93
BRCA-familial	12kDiscoControls_10xGenes	0.01	-0.34	0.64	0.67	4.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes	96	96	
BRCA-familial	23	23