Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	7.47e-02	1.04e-03	1.86e-07	9.21e-18
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	1.81e-02	3.30e-01	3.57e-10	5.19e-04
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	1.08e-01	8.40e-04	4.67e-07	2.81e-17
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	2.13e-02	3.71e-01	4.42e-09	8.03e-04
12kDiscoControls_10xGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
BRCA-somatic Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	7.92e-02
Overlap	Exclusives	1.34e-04	2.45e-02	2.52e-15	9.57e-09



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	0.88	1.29	4.85	2.11	8.79
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	0.63	1.93	1.35	1.00	4.58
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	0.88	1.00	5.40	1.88	7.80
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	0.63	1.99	1.26	0.70	4.66
12kDiscoControls_10xGenes Exclusive	Overlap	0.97	1.22	1.22	1.32	1.74
BRCA-somatic Exclusive	Overlap	0.98	0.75	1.64	1.69	1.77
Overlap	Exclusives	0.66	-0.13	0.20	0.31	6.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	0.01	-1.04	7.07	0.74	11.15
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	0.01	0.48	3.89	3.19	5.07
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.14	6.06	0.41	2.01
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	0.01	0.45	2.73	2.20	2.31
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	0.65	7.27	1.98	3.38
BRCA-somatic Exclusive	Overlap	0.00	0.15	15.84	5.14	0.37
Overlap	Exclusives	0.02	4.13	6.69	1.97	7.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	95	95	
BRCA-somatic Exclusive	36	36	
Overlap	1	1