Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial	4.75e-12	1.23e-08	1.14e-19	8.60e-20
BRCA-familial Exclusive	12kDiscoCases_10xGenes	6.75e-04	6.80e-03	5.45e-18	1.89e-08
12kDiscoCases_10xGenes Exclusive	BRCA-familial Exclusive	5.64e-07	2.97e-05	5.15e-11	4.04e-12
BRCA-familial Exclusive	12kDiscoCases_10xGenes Exclusive	1.97e-02	1.46e-01	3.86e-18	1.54e-07
12kDiscoCases_10xGenes Exclusive	Overlap	2.41e-07	2.95e-06	1.06e-08	1.73e-10
BRCA-familial Exclusive	Overlap	1.78e-21	1.46e-15	1.78e-21	2.04e-17
Overlap	Exclusives	2.33e-04	1.87e-03	1.38e-21	1.71e-10



Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial	0.96	2.34	6.56	2.59	7.60
BRCA-familial Exclusive	12kDiscoCases_10xGenes	0.68	1.67	3.83	1.35	6.68
12kDiscoCases_10xGenes Exclusive	BRCA-familial Exclusive	0.96	1.93	5.40	2.38	6.72
BRCA-familial Exclusive	12kDiscoCases_10xGenes Exclusive	0.66	1.57	2.93	1.06	7.09
12kDiscoCases_10xGenes Exclusive	Overlap	0.97	2.34	4.01	2.22	5.25
BRCA-familial Exclusive	Overlap	1.00	3.42	4.97	3.36	4.84
Overlap	Exclusives	0.68	1.17	3.87	1.23	7.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-familial	0.02	0.38	13.58	7.62	45.60
BRCA-familial Exclusive	12kDiscoCases_10xGenes	0.04	10.56	33.42	15.88	42.68
12kDiscoCases_10xGenes Exclusive	BRCA-familial Exclusive	0.01	1.52	6.63	5.73	22.96
BRCA-familial Exclusive	12kDiscoCases_10xGenes Exclusive	0.02	3.59	11.30	5.06	17.12
12kDiscoCases_10xGenes Exclusive	Overlap	0.01	-0.35	6.64	2.31	13.62
BRCA-familial Exclusive	Overlap	0.21	93.75	445.89	324.11	160.70
Overlap	Exclusives	0.04	6.36	23.81	11.39	25.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_10xGenes Exclusive	145	145	
BRCA-familial Exclusive	14	14	
Overlap	9	9