Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	1.38e-02	7.86e-02	3.25e-07	1.07e-12
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	1.15e-04	1.49e-02	3.11e-13	2.48e-05
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	1.40e-02	7.17e-02	3.14e-07	1.21e-12
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	1.31e-04	2.17e-02	3.05e-13	2.69e-05
12kDiscoCases_10xGenes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
BRCA-somatic Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.61e-04	6.42e-12	8.46e-138	6.78e-28



Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	0.86	-0.08	2.36	1.17	6.97
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	0.62	-0.23	0.95	0.68	4.76
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	0.86	-0.30	2.33	1.33	7.04
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	0.62	-0.14	1.01	0.63	4.76
12kDiscoCases_10xGenes Exclusive	Overlap	1.00	-7.37	inf	0.12	1.95
BRCA-somatic Exclusive	Overlap	1.00	-1.84	inf	1.19	1.85
Overlap	Exclusives	0.75	83801821852434.50	10.14	2.17	12.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	0.01	-1.50	4.13	0.30	13.88
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	0.02	-0.06	2.98	3.02	6.74
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.49	3.83	0.65	10.15
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	0.02	0.29	2.61	3.20	9.29
12kDiscoCases_10xGenes Exclusive	Overlap	0.01	-0.74	9309766671566916.00	-0.48	50.45
BRCA-somatic Exclusive	Overlap	0.01	-0.51	12993533296929312.00	10.45	46.18
Overlap	Exclusives	0.03	987760483279674.00	14.83	2.46	15.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_10xGenes Exclusive	153	153	
BRCA-somatic Exclusive	36	36	
Overlap	1	1