Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-gwas	2.33e-03	7.79e-01	1.53e-04	4.93e-05
BRCA-gwas Exclusive	12kDiscoCases_10xGenes	1.14e-01	8.76e-01	3.66e-05	3.05e-04
12kDiscoCases_10xGenes Exclusive	BRCA-gwas Exclusive	2.16e-03	8.29e-01	7.45e-04	1.57e-04
BRCA-gwas Exclusive	12kDiscoCases_10xGenes Exclusive	7.32e-02	9.04e-01	3.53e-04	1.32e-03
12kDiscoCases_10xGenes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	3.66e-05
BRCA-gwas Exclusive	Overlap	1.23e-01	7.71e-02	6.18e-03	8.82e-04
Overlap	Exclusives	5.93e-03	5.37e-03	8.15e-55	2.53e-12



Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-gwas	0.61	-0.53	0.64	0.81	5.69
BRCA-gwas Exclusive	12kDiscoCases_10xGenes	0.61	-0.72	-0.35	0.64	4.65
12kDiscoCases_10xGenes Exclusive	BRCA-gwas Exclusive	0.61	-0.69	0.62	0.68	5.09
BRCA-gwas Exclusive	12kDiscoCases_10xGenes Exclusive	0.60	-0.73	-0.33	0.22	4.04
12kDiscoCases_10xGenes Exclusive	Overlap	0.99	1.16	2.72	1.58	2.94
BRCA-gwas Exclusive	Overlap	0.97	0.40	2.01	1.06	3.05
Overlap	Exclusives	0.65	1.42	4.03	1.24	8.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-gwas	0.01	-1.37	0.71	0.71	4.73
BRCA-gwas Exclusive	12kDiscoCases_10xGenes	0.02	2.41	9.94	9.38	24.07
12kDiscoCases_10xGenes Exclusive	BRCA-gwas Exclusive	0.01	-1.67	0.38	0.25	3.64
BRCA-gwas Exclusive	12kDiscoCases_10xGenes Exclusive	0.02	2.61	9.05	8.13	18.39
12kDiscoCases_10xGenes Exclusive	Overlap	0.01	1.25	25.49	5.95	8.63
BRCA-gwas Exclusive	Overlap	0.01	1.16	15.75	5.03	18.06
Overlap	Exclusives	0.03	6.53	9.98	4.24	16.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_10xGenes Exclusive	151	151	
BRCA-gwas Exclusive	170	170	
Overlap	3	3