Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	1.93e-02	7.16e-02	1.11e-06	1.31e-13
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	1.52e-03	1.20e-01	1.37e-11	8.31e-05
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	7.91e-02	6.56e-02	4.91e-06	6.47e-11
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	2.49e-03	2.08e-01	5.51e-12	3.95e-04
12kDiscoCases_10xGenes Exclusive	Overlap	4.36e-07	7.71e-02	4.36e-07	1.74e-06
BRCA-somatic Exclusive	Overlap	4.36e-07	1.25e-04	4.36e-07	1.74e-06
Overlap	Exclusives	1.32e-11	1.12e-09	1.30e-75	1.04e-24



Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	0.86	-0.22	2.61	1.18	8.32
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	0.62	-0.04	0.88	0.57	5.59
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	0.85	-0.35	2.01	1.05	7.15
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	0.62	0.17	0.82	0.64	5.83
12kDiscoCases_10xGenes Exclusive	Overlap	0.99	1.22	1.68	1.32	3.39
BRCA-somatic Exclusive	Overlap	1.00	1.38	2.55	1.84	2.60
Overlap	Exclusives	0.74	1.17	7.38	2.30	10.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoCases_10xGenes Exclusive	BRCA-somatic	0.01	-1.68	4.73	0.35	3.51
BRCA-somatic Exclusive	12kDiscoCases_10xGenes	0.02	-0.27	2.95	2.55	7.88
12kDiscoCases_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-1.47	2.82	-0.03	2.05
BRCA-somatic Exclusive	12kDiscoCases_10xGenes Exclusive	0.01	-0.22	1.20	1.61	8.30
12kDiscoCases_10xGenes Exclusive	Overlap	0.01	-0.67	7.61	1.48	30.52
BRCA-somatic Exclusive	Overlap	0.02	-0.34	17.79	21.76	4.27
Overlap	Exclusives	0.04	5.37	26.89	8.94	23.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoCases_10xGenes Exclusive	156	156	
BRCA-somatic Exclusive	34	34	
Overlap	3	3