Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas 3.57e-03 7.20e-01 1.21e-04 1.30e-05 BRCA-gwas Exclusive 12kDiscoCases_10xGenes 4.64e-02 5.62e-01 9.45e-05 1.39e-04 12kDiscoCases_10xGenes Exclusive BRCA-gwas Exclusive 5.91e-03 7.91e-01 5.42e-04 6.96e-05 BRCA-gwas Exclusive 12kDiscoCases_10xGenes Exclusive 2.47e-02 4.36e-01 2.38e-04 1.79e-04 12kDiscoCases_10xGenes Exclusive Overlap 1.83e-09 2.31e-05 1.83e-09 1.31e-06 BRCA-gwas Exclusive Overlap 2.62e-02 1.67e-02 4.47e-03 4.95e-04 Overlap Exclusives 8.60e-04 3.38e-04 1.34e-57 1.95e-14 Evaluating how well 12kDiscoCases_10xGenes genes are linked to BRCA-gwas genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas 0.62 -0.36 0.85 0.94 5.67 BRCA-gwas Exclusive 12kDiscoCases_10xGenes 0.61 -0.65 -0.25 0.23 4.33 12kDiscoCases_10xGenes Exclusive BRCA-gwas Exclusive 0.61 -0.53 0.60 0.70 4.65 BRCA-gwas Exclusive 12kDiscoCases_10xGenes Exclusive 0.60 -0.89 -0.64 0.39 4.36 12kDiscoCases_10xGenes Exclusive Overlap 0.99 1.26 3.01 1.59 3.64 BRCA-gwas Exclusive Overlap 0.97 0.42 2.22 1.13 3.24 Overlap Exclusives 0.66 1.76 5.21 1.88 10.06 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 12kDiscoCases_10xGenes Exclusive BRCA-gwas 0.01 -1.39 1.17 0.90 6.55 BRCA-gwas Exclusive 12kDiscoCases_10xGenes 0.03 2.65 11.31 10.43 21.46 12kDiscoCases_10xGenes Exclusive BRCA-gwas Exclusive 0.01 -2.00 0.01 0.22 4.78 BRCA-gwas Exclusive 12kDiscoCases_10xGenes Exclusive 0.02 2.68 9.59 7.16 24.23 12kDiscoCases_10xGenes Exclusive Overlap 0.01 1.41 17.79 5.95 30.24 BRCA-gwas Exclusive Overlap 0.01 0.54 12.90 4.33 4.11 Overlap Exclusives 0.04 6.13 12.62 5.21 19.63 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 12kDiscoCases_10xGenes Exclusive 155 155 BRCA-gwas Exclusive 169 169 Overlap 4 4