Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	1.20e-02	1.49e-04	1.80e-14	4.57e-17
BRCA-familial Exclusive	12kDiscoControls_10xGenes	1.45e-04	9.93e-02	6.70e-14	8.46e-12
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	6.92e-02	1.22e-03	3.51e-13	6.59e-16
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	1.63e-04	1.59e-01	5.94e-13	5.06e-11
12kDiscoControls_10xGenes Exclusive	Overlap	5.42e-03	7.30e-02	9.85e-05	1.68e-02
BRCA-familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	7.51e-10	3.68e-03	1.60e-03	3.88e-05



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	0.93	1.08	3.68	1.93	7.20
BRCA-familial Exclusive	12kDiscoControls_10xGenes	0.69	-0.25	2.01	1.47	9.15
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	0.93	0.98	3.94	2.09	8.26
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	0.68	-0.18	1.60	1.61	8.56
12kDiscoControls_10xGenes Exclusive	Overlap	0.93	1.11	1.59	1.58	1.99
BRCA-familial Exclusive	Overlap	1.00	1.66	2.20	2.42	2.23
Overlap	Exclusives	0.61	-2.07	-2.95	-0.76	5.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-familial	0.01	-1.04	2.09	1.03	24.95
BRCA-familial Exclusive	12kDiscoControls_10xGenes	0.02	0.42	4.05	3.23	8.76
12kDiscoControls_10xGenes Exclusive	BRCA-familial Exclusive	0.01	-1.22	1.55	1.07	27.77
BRCA-familial Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.34	1.89	3.06	11.19
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	0.33	0.56	1.14	0.10
BRCA-familial Exclusive	Overlap	0.10	99.84	524.06	410.99	27.55
Overlap	Exclusives	0.03	2.57	8.43	3.18	19.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	165	164	TFDP2
BRCA-familial Exclusive	21	21	
Overlap	2	2