Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	4.32e-02	1.26e-02	4.22e-08	6.58e-13
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	2.73e-04	3.15e-02	1.91e-18	8.64e-10
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	3.23e-01	7.36e-02	1.11e-06	1.12e-11
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	2.85e-04	5.28e-02	7.64e-18	2.22e-08
12kDiscoControls_10xGenes Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
BRCA-somatic Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.93e-17	7.03e-14	2.57e-76	4.10e-33



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	0.87	-1.07	2.58	1.52	7.73
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	0.67	-0.26	2.02	1.34	8.01
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	0.86	-1.09	2.19	1.27	7.85
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	0.67	-0.10	2.21	1.57	6.90
12kDiscoControls_10xGenes Exclusive	Overlap	1.00	1.04	3.26	1.35	3.26
BRCA-somatic Exclusive	Overlap	0.99	1.14	2.16	1.80	3.17
Overlap	Exclusives	0.79	2.92	10.57	2.31	16.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-somatic	0.02	-1.66	7.82	2.98	47.08
BRCA-somatic Exclusive	12kDiscoControls_10xGenes	0.02	-0.22	3.65	2.05	10.77
12kDiscoControls_10xGenes Exclusive	BRCA-somatic Exclusive	0.01	-2.18	3.42	0.96	24.46
BRCA-somatic Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.17	3.09	2.36	10.12
12kDiscoControls_10xGenes Exclusive	Overlap	0.05	4.16	26.66	24.38	329.73
BRCA-somatic Exclusive	Overlap	0.01	0.01	24.27	12.28	51.12
Overlap	Exclusives	0.05	5.92	29.90	7.94	56.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	164	163	TFDP2
BRCA-somatic Exclusive	34	34	
Overlap	3	3