Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	7.33e-03	4.42e-01	1.44e-08	4.34e-05
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	3.50e-03	9.13e-02	1.95e-13	8.73e-10
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	1.20e-02	4.15e-01	4.61e-08	2.93e-05
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	3.45e-03	6.86e-02	1.83e-13	1.73e-09
12kDiscoControls_10xGenes Exclusive	Overlap	3.96e-01	3.56e-01	1.19e-01	3.56e-01
BRCA-gwas Exclusive	Overlap	6.14e-01	5.15e-01	7.72e-01	4.75e-01
Overlap	Exclusives	3.59e-10	7.45e-01	1.04e-33	6.39e-13



Evaluating how well 12kDiscoControls_10xGenes genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	0.62	-0.44	0.56	1.38	6.26
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	0.67	-0.98	1.05	1.05	7.35
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	0.62	-0.39	0.62	1.14	5.17
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	0.67	-1.10	1.11	1.33	7.56
12kDiscoControls_10xGenes Exclusive	Overlap	0.86	0.67	0.82	0.55	1.14
BRCA-gwas Exclusive	Overlap	0.75	-0.34	0.61	0.01	0.90
Overlap	Exclusives	0.62	-0.26	0.22	0.24	8.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
12kDiscoControls_10xGenes Exclusive	BRCA-gwas	0.02	-1.95	0.67	2.37	9.65
BRCA-gwas Exclusive	12kDiscoControls_10xGenes	0.02	-0.18	3.76	3.93	17.46
12kDiscoControls_10xGenes Exclusive	BRCA-gwas Exclusive	0.02	-1.80	0.99	2.14	9.00
BRCA-gwas Exclusive	12kDiscoControls_10xGenes Exclusive	0.02	-0.21	4.04	2.90	7.37
12kDiscoControls_10xGenes Exclusive	Overlap	0.00	-0.13	0.57	-0.15	0.21
BRCA-gwas Exclusive	Overlap	0.00	-0.50	-0.20	-0.18	-0.14
Overlap	Exclusives	0.03	-0.20	-0.13	0.12	8.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
12kDiscoControls_10xGenes Exclusive	166	165	TFDP2
BRCA-gwas Exclusive	172	172	
Overlap	1	1